Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4584006 | 0.85 | HTR6 (0.41) | HTR6CCNCCDK8CYP2C19CDK2 | |
| SCHEMBL8233323 | 0.80 | HTR6 (0.39) | HTR6CCNCCDK8CYP2C19CDK2 | |
| SCHEMBL4582983 | 0.79 | CCNC (0.43) | HTR6CCNCCDK8CYP2C19CDK2 | |
| SCHEMBL3355302 | 0.76 | HTR6 (0.45) | HTR6CCNCCDK8CYP2C19CDK2 | |
| SCHEMBL17165465 | 0.73 | CCNC (0.52) | HTR6CCNCCDK8CYP2C19CDK2 | |
| SCHEMBL2529105 | 0.73 | HTR6 (0.51) | HTR6CCNCCDK8CYP2C19CDK2 | |
| SCHEMBL1049986 | 0.73 | CYP2C19 (0.49) | HTR6CCNCCDK8CYP2C19CDK2 | |
| SCHEMBL4584452 | 0.73 | HTR6 (0.44) | HTR6CCNCCDK8CYP2C19CDK2 | |
| SCHEMBL1584951 | 0.72 | HTR6 (0.47) | HTR6CCNCCDK8CYP2C19CDK2 | |
| SCHEMBL8944259 | 0.72 | L3MBTL1 (0.67) | HTR6CCNCCDK8CYP2C19PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |