Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.68 |
| ▸ | PLK1 | P53350 | 1/20 | 0.61 |
| ▸ | JAK3 | P52333 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 4/20 | 0.61 |
| ▸ | BCR | P11274 | 4/20 | 0.61 |
| ▸ | PRKCA | P17252 | 3/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.59 |
| ▸ | SRC | P12931 | 3/20 | 0.58 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.58 |
| ▸ | SYK | P43405 | 6/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.56 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | PRKCG | P05129 | 1/20 | 0.56 |
| ▸ | PRKCB | P05771 | 1/20 | 0.56 |
| ▸ | PRKCH | P24723 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7461995 | 0.89 | JAK2 (0.73) | JAK2PLK1JAK3AURKASYK | |
| SCHEMBL3123402 | 0.87 | ABL1 (0.74) | JAK2ABL1BCRPRKCASRC | |
| SCHEMBL4900774 | 0.86 | ABL1 (0.59) | JAK2ABL1BCRPRKCASRC | |
| SCHEMBL4899247 | 0.84 | ABL1 (0.73) | JAK2ABL1BCRPRKCASRC | |
| SCHEMBL7475764 | 0.83 | JAK2 (0.71) | JAK2PLK1JAK3ABL1BCR | |
| SCHEMBL7463871 | 0.82 | ABL1 (0.70) | ABL1BCRPRKCAAURKASRC | |
| SCHEMBL4901723 | 0.82 | ABL1 (0.64) | JAK2ABL1BCRPRKCAAURKA | |
| SCHEMBL4903283 | 0.82 | ABL1 (0.61) | JAK2ABL1BCRPRKCASRC | |
| SCHEMBL4905620 | 0.82 | ABL1 (0.64) | JAK2ABL1BCRPRKCASRC | |
| SCHEMBL7468958 | 0.82 | ABL1 (0.76) | JAK2PLK1ABL1BCRPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |