Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384197 | 0.79 | HDAC1 (0.47) | HDAC4HDAC6ALDH1A1KMT2AMEN1 | |
| SCHEMBL4582625 | 0.70 | ALDH1A1 (0.44) | HDAC4HDAC6ALDH1A1KMT2AMEN1 | |
| SCHEMBL4389462 | 0.70 | HDAC1 (0.45) | ALDH1A1KMT2AMEN1HDAC1HPGD | |
| SCHEMBL4382189 | 0.69 | ACKR3 (0.43) | HDAC4ALDH1A1KMT2AMEN1GAA | |
| SCHEMBL4375386 | 0.69 | ACKR3 (0.43) | HDAC4ALDH1A1KMT2AMEN1GAA | |
| SCHEMBL4380601 | 0.66 | SLC6A4 (0.47) | ALDH1A1KMT2AMEN1HPGDLMNA | |
| SCHEMBL9943767 | 0.66 | DAO (0.44) | HDAC6ALDH1A1KMT2AMEN1GAA | |
| SCHEMBL13884377 | 0.65 | HDAC4 (0.45) | HDAC4HDAC6KMT2AMEN1TP53 | |
| SCHEMBL4377187 | 0.65 | DPP4 (0.43) | ALDH1A1KMT2ALMNARIPK1 | |
| SCHEMBL4373941 | 0.65 | DPP4 (0.43) | ALDH1A1KMT2ALMNARIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |