Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4382189 | 1.00 | ACKR3 (0.43) | ACKR3MEN1KMT2AMAPTGAA | |
| SCHEMBL4378512 | 0.84 | AKT1 (0.40) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL4583485 | 0.83 | ALDH1A1 (0.47) | MEN1KMT2ALMNAALDH1A1L3MBTL1 | |
| SCHEMBL4374524 | 0.83 | ALDH1A1 (0.47) | MEN1KMT2ALMNAALDH1A1L3MBTL1 | |
| SCHEMBL4373621 | 0.83 | AKT1 (0.39) | KMT2A | |
| SCHEMBL4380031 | 0.83 | AKT1 (0.39) | KMT2A | |
| SCHEMBL4384197 | 0.82 | HDAC1 (0.47) | ACKR3MEN1KMT2AMAPTGAA | |
| SCHEMBL4377324 | 0.81 | PYGL (0.38) | KMT2AL3MBTL1RAB9ANPC1CTSL | |
| SCHEMBL4582450 | 0.80 | CTRB1 (0.38) | KMT2ALMNARAB9ANPC1CTSL | |
| SCHEMBL4379225 | 0.79 | ANPEP (0.36) | KMT2AL3MBTL1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |