SCHEMBL458334

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL459961	0.91	PIK3CG (0.46)	ITKABL1PIK3CGRAB9AHTT
	SCHEMBL458913	0.91	PIK3CG (0.56)	ITKABL1PIK3CGRAB9AHTT
	SCHEMBL458364	0.89	TRPV1 (0.44)	ITKABL1PIK3CGRAB9AHTT
	SCHEMBL15103274	0.87	NPC1 (0.52)	RAB9ANPC1SMN1; SMN2HPGDSPIK3CA
	SCHEMBL460334	0.86	TRPV1 (0.47)	RAB9AHTTTRPV1NPC1MAPT
	SCHEMBL460061	0.86	HPGDS (0.55)	RAB9AHTTTRPV1NPC1MAPT
	SCHEMBL460519	0.86	PIK3CG (0.58)	ABL1PIK3CGRAB9AHTTTRPV1
	SCHEMBL458405	0.86	ABL1 (0.47)	ABL1PIK3CGTRPV1MAPTKDM4E
	SCHEMBL460191	0.84	RAB9A (0.44)	ABL1RAB9AHTTTRPV1NPC1
	SCHEMBL460598	0.83	DYRK1A (0.52)	RAB9AHTTNPC1MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.