Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583410 | 0.90 | ALDH1A1 (0.47) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL1539533 | 0.89 | KMT2A (0.39) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL4374678 | 0.89 | KMT2A (0.47) | KMT2APOLBALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL3724996 | 0.86 | SMN1; SMN2 (0.37) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL4374146 | 0.84 | KMT2A (0.41) | KMT2AMEN1NPC1RAB9APOLB | |
| SCHEMBL4381679 | 0.82 | MEN1 (0.47) | KMT2AMEN1NPC1RAB9ACA12 | |
| SCHEMBL4073210 | 0.77 | CYP3A4 (0.46) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL1273081 | 0.77 | CYP3A4 (0.46) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL4583207 | 0.76 | CYP3A4 (0.50) | NPC1RAB9AALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL16757585 | 0.75 | CYP2C9 (0.44) | NPC1RAB9APOLBALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |