Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583697 | 0.84 | KMT2A (0.48) | KMT2AMEN1POLBCHRM2CA12 | |
| SCHEMBL3724996 | 0.83 | SMN1; SMN2 (0.37) | KMT2AMEN1POLBTSHRCA12 | |
| SCHEMBL1539533 | 0.83 | KMT2A (0.39) | KMT2AMEN1POLBCA12CA9 | |
| SCHEMBL4381679 | 0.80 | MEN1 (0.47) | KMT2AMEN1CA12CA9ALDH1A1 | |
| SCHEMBL4374632 | 0.79 | GUCY1B2 (0.36) | KMT2AMEN1POLBNPC1RAB9A | |
| SCHEMBL4583410 | 0.77 | ALDH1A1 (0.47) | KMT2AMEN1POLBALDH1A1NPC1 | |
| SCHEMBL4374678 | 0.76 | KMT2A (0.47) | KMT2APOLBALDH1A1ATM | |
| SCHEMBL4374642 | 0.69 | CA12 (0.42) | KMT2AMEN1CHRM2CA12CA9 | |
| SCHEMBL16266052 | 0.66 | CA12 (0.47) | KMT2AMEN1POLBCA12CA9 | |
| SCHEMBL28655810 | 0.66 | CA12 (0.55) | KMT2AMEN1CHRM2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |