Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRB1 | P17538 | 5/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.43 |
| ▸ | CTSL | P07711 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | PRKX | P51817 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3509771 | 0.77 | CTRB1 (0.42) | CTRB1PIN1CTSLTP53HPGD | |
| SCHEMBL11884009 | 0.76 | CTRB1 (0.49) | CTRB1MAPK1MMENPC1RAB9A | |
| SCHEMBL4581842 | 0.75 | ALDH1A1 (0.40) | CTRB1KLK7CTSLALDH1A1LMNA | |
| SCHEMBL3506437 | 0.75 | ALDH1A1 (0.48) | CTRB1PIN1CTSLALDH1A1LMNA | |
| SCHEMBL3506435 | 0.75 | ALDH1A1 (0.48) | CTRB1PIN1CTSLALDH1A1LMNA | |
| SCHEMBL3511843 | 0.75 | ALDH1A1 (0.48) | CTRB1PIN1CTSLALDH1A1LMNA | |
| SCHEMBL3509337 | 0.74 | AKT1 (0.48) | CTRB1PIN1ALDH1A1LMNAGSK3B | |
| SCHEMBL3505511 | 0.73 | KMT2A (0.48) | CTRB1PIN1ALDH1A1LMNAHPGD | |
| SCHEMBL3507223 | 0.72 | CTRB1 (0.42) | CTRB1PIN1CTSLALDH1A1HPGD | |
| SCHEMBL3510049 | 0.72 | KMT2A (0.41) | CTRB1PIN1CTSLALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |