Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CCR1 | P32246 | 2/20 | 0.37 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CTRB1 | P17538 | 5/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4582505 | 0.81 | HPGD (0.54) | ALDH1A1LMNAHPGDSMN1; SMN2KMT2A | |
| SCHEMBL4582450 | 0.80 | CTRB1 (0.38) | LMNAKMT2ACCR1CTSLNPC1 | |
| SCHEMBL4381061 | 0.79 | RAB9A (0.41) | ALDH1A1HPGDSMN1; SMN2KMT2ACCR1 | |
| SCHEMBL4374524 | 0.77 | ALDH1A1 (0.47) | ALDH1A1LMNAHPGDSMN1; SMN2KMT2A | |
| SCHEMBL4583485 | 0.77 | ALDH1A1 (0.47) | ALDH1A1LMNAHPGDSMN1; SMN2KMT2A | |
| SCHEMBL4378512 | 0.76 | AKT1 (0.40) | ALDH1A1LMNAHPGDKMT2ACCR1 | |
| SCHEMBL4375386 | 0.76 | ACKR3 (0.43) | ALDH1A1LMNAHPGDSMN1; SMN2KMT2A | |
| SCHEMBL4382189 | 0.76 | ACKR3 (0.43) | ALDH1A1LMNAHPGDSMN1; SMN2KMT2A | |
| SCHEMBL4543936 | 0.75 | KMT2A (0.41) | HSD17B10KMT2ACCR1CTSLCTRB1 | |
| SCHEMBL4583765 | 0.75 | CTRB1 (0.47) | ALDH1A1LMNATP53HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |