Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29157428 | 0.86 | MAPT (0.74) | MAPTLMNAMAPK1SMN1; SMN2TSHR | |
| SCHEMBL3767565 | 0.86 | MAPT (0.74) | MAPTLMNAMAPK1SMN1; SMN2TSHR | |
| SCHEMBL3765754 | 0.86 | RAB9A (0.66) | MAPTLMNAMAPK1SMN1; SMN2TSHR | |
| SCHEMBL13208949 | 0.86 | MAPT (0.58) | MAPTLMNAMAPK1SMN1; SMN2TSHR | |
| SCHEMBL17541711 | 0.85 | MAPT (0.67) | MAPTLMNAMAPK1SMN1; SMN2TSHR | |
| SCHEMBL1473079 | 0.85 | MAPT (0.58) | MAPTLMNAMAPK1SMN1; SMN2TSHR | |
| SCHEMBL27315644 | 0.82 | LMNA (0.59) | MAPTLMNAMAPK1SMN1; SMN2TSHR | |
| SCHEMBL1118307 | 0.81 | GPR119 (0.67) | GPR119 | |
| SCHEMBL3767461 | 0.79 | MAPT (0.54) | MAPTLMNAMAPK1SMN1; SMN2TSHR | |
| SCHEMBL3778538 | 0.78 | SMN1; SMN2 (0.59) | MAPTLMNAMAPK1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |