Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 6/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | ATF4 | P18848 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8182207 | 0.86 | ADRB2 (0.52) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| SCHEMBL4573880 | 0.86 | ADRB2 (0.52) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| SCHEMBL5799574 | 0.85 | LMNA (0.61) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| SCHEMBL5814362 | 0.85 | LMNA (0.61) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| SCHEMBL14027346 | 0.82 | POLB (0.63) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| SCHEMBL8181088 | 0.80 | KMT2A (0.60) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| SCHEMBL4573726 | 0.80 | KMT2A (0.60) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| SCHEMBL5257329 | 0.80 | ADRB3 (0.66) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| SCHEMBL4897732 | 0.75 | MEN1 (0.42) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| SCHEMBL4574895 | 0.75 | MEN1 (0.42) | ADRB2ADRB1ADRB3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008058198-A1 | METHODS OF MAKING COMPOUNDS HAVING A BETA-ADRENERGIC INHIBITOR AND A LINKER AND METHODS OF MAKING COMPOUNDS HAVING A BETA-ADRENERGIC INHIBITOR, A LINKER AND A PHOSPHODIESTERASE INHIBITOR | CARDIOME PHARMA CORP. (CA) | 2008-05-15 | — | — | WO | disclosed |