Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 4/20 | 0.34 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 5/20 | 0.31 |
| ▸ | BRAF | P15056 | 3/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4585467 | 0.90 | EGFR (0.35) | MEN1LMNAPOLBKMT2ASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL4585475 | 0.90 | EGFR (0.35) | MEN1LMNAPOLBKMT2ASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5049812 | 0.89 | DHODH (0.38) | MEN1KMT2AEGFRCISD1HDAC4 | |
| Trifluoroacetic Acid SCHEMBL2991044 | 0.89 | DHODH (0.38) | MEN1KMT2AEGFRCISD1HDAC4 | |
| SCHEMBL4586165 | 0.88 | RAB9A (0.37) | MEN1POLBKMT2ASMN1; SMN2EGFR | |
| SCHEMBL4586191 | 0.83 | ALDH1A1 (0.37) | MEN1KMT2AEGFRESR1 | |
| SCHEMBL2992632 | 0.82 | DYRK3 (0.44) | MEN1POLBKMT2AEGFRACKR3 | |
| SCHEMBL2992635 | 0.82 | DYRK3 (0.44) | MEN1POLBKMT2AEGFRACKR3 | |
| SCHEMBL2998969 | 0.80 | DYRK3 (0.44) | KMT2ASMN1; SMN2EGFRACKR3 | |
| SCHEMBL2998972 | 0.80 | DYRK3 (0.44) | KMT2ASMN1; SMN2EGFRACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879563-A4 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1879563-A2 | NOVEL CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006132739-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-12-14 | — | — | WO | disclosed |