Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.80 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.80 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.80 |
| ▸ | PRKACA | P17612 | 2/20 | 0.80 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.80 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.80 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.80 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.80 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.80 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.80 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.80 |
| ▸ | PRKCG | P05129 | 1/20 | 0.80 |
| ▸ | LCK | P06239 | 1/20 | 0.80 |
| ▸ | LYN | P07948 | 1/20 | 0.80 |
| ▸ | RET | P07949 | 1/20 | 0.80 |
| ▸ | PIM1 | P11309 | 1/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.80 |
| ▸ | FLT4 | P35916 | 1/20 | 0.80 |
| ▸ | KDR | P35968 | 1/20 | 0.80 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7893693 | 0.92 | MAPK14 (0.69) | MAPK14PRKD3MAP4K4PRKACACSNK1A1 | |
| SCHEMBL8655729 | 0.90 | MAPK14 (0.90) | MAPK14PRKD3MAP4K4PRKACACSNK1A1 | |
| Sb-220025 SCHEMBL173441 | 0.89 | MAPK14 (1.00) | MAPK14PRKD3MAP4K4PRKACACSNK1A1 | |
| SCHEMBL7772152 | 0.89 | MAPK14 (0.82) | MAPK14PRKD3MAP4K4PRKACACSNK1A1 | |
| Sb-220025 SCHEMBL18066291 | 0.88 | MAPK14 (0.98) | MAPK14PRKD3MAP4K4PRKACACSNK1A1 | |
| SCHEMBL7136557 | 0.87 | MAPK14 (0.77) | MAPK14PRKD3MAP4K4PRKACACSNK1A1 | |
| SCHEMBL4915514 | 0.87 | MAPK14 (0.80) | MAPK14PRKD3MAP4K4PRKACACSNK1A1 | |
| SCHEMBL4915688 | 0.84 | MAPK14 (0.73) | MAPK14PRKD3MAP4K4PRKACACSNK1A1 | |
| SCHEMBL1640306 | 0.84 | MAPK14 (1.00) | MAPK14PRKD3MAP4K4PRKACACSNK1A1 | |
| SCHEMBL13167691 | 0.84 | MAPK14 (0.81) | MAPK14PRKD3MAP4K4PRKACACSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539121-A4 | METHODS OF PROMOTING OSTEOGENESIS | SCIOS INC (US) | 2008-08-13 | — | — | EP | disclosed |
| US-20080108658-A1 | METHODS OF PROMOTING OSTEOGENESIS | PROTTER ANDREW A | 2008-05-08 | — | — | US | disclosed |
| US-20080039461-A1 | Treatment of pain by inhibition of p38 map kinase | PROTTER ANDREW A | 2008-02-14 | — | — | US | disclosed |
| US-7268139-B2 | Methods of promoting osteogenesis | SCIOS, INC. (US) | 2007-09-11 | — | — | US | disclosed |
| US-7244441-B2 | Stents and intra-luminal prostheses containing map kinase inhibitors | SCIOS, INC. (US) | 2007-07-17 | — | — | US | disclosed |
| EP-1676574-A2 | Methods for promoting survival of transplanted tissues and cells | Johnson & Johnson Vision Care, Inc. (US) | 2006-07-05 | — | — | EP | disclosed |
| US-20060019971-A1 | Treatment of cardiovascular disease with inhibitors of p38 kinase | SCIOS INC. | 2006-01-26 | — | — | US | disclosed |
| US-20050129729-A1 | Stents and intra-luminal prostheses containing map kinase inhibitors | SCIOS, INC. | 2005-06-16 | — | — | US | disclosed |
| EP-1539121-A2 | METHODS OF PROMOTING OSTEOGENESIS | SCIOS INC. (US) | 2005-06-15 | — | — | EP | disclosed |
| US-20040171659-A1 | Methods for treating diabetes | SCIOS, INC. | 2004-09-02 | — | — | US | disclosed |
| US-20040162289-A1 | Methods of promoting osteogenesis | UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY | 2004-08-19 | — | — | US | disclosed |
| US-20040122008-A1 | Treatment of pain by inhibition of p38 MAP kinase | SCIOS, INC. | 2004-06-24 | — | — | US | disclosed |
| WO-2004019873-A2 | METHODS OF PROMOTING OSTEOGENESIS | SCIOS INC. (US) | 2004-03-11 | — | — | WO | disclosed |
| US-6214844-B1 | ANTIARTHRITIC AGENTS; BONE DISORDERS; ANTIINFLAMMATORY AGENTS | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | disclosed |
| US-6096739-A | Treatment for CNS injuries | SMITHKLINE BEECHAM CORPORATION (US) | 2000-08-01 | — | — | US | disclosed |
| US-5811549-A | Process of preparing imidazole compounds | SMITHKLINE BEECHAM (US) | 1998-09-22 | — | — | US | disclosed |
| US-5716955-A | Substituted imidazole compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060019971-A1 | Treatment of cardiovascular disease with inhibitors of p38 kinase | MAPKAPK5, MAPK1, MAPKAPK2 | MAPK14 36/4885PRKD3 117/4885MAP4K4 32/4885 |
| US-20080108658-A1 | METHODS OF PROMOTING OSTEOGENESIS | MAPK1, BMP2, MAPK3 | MAPK14 23/4885PRKD3 196/4885MAP4K4 55/4885 |
| US-20040162289-A1 | Methods of promoting osteogenesis | MAPK1, BMP2, MAPK3 | MAPK14 23/4885PRKD3 196/4885MAP4K4 55/4885 |
| US-20040122008-A1 | Treatment of pain by inhibition of p38 MAP kinase | OPRK1, OPRL1, MAPK3 | MAPK14 36/4885PRKD3 568/4885MAP4K4 37/4885 |
| US-20080039461-A1 | Treatment of pain by inhibition of p38 map kinase | OPRK1, OPRL1, MAPK3 | MAPK14 36/4885PRKD3 568/4885MAP4K4 37/4885 |
| US-20040171659-A1 | Methods for treating diabetes | SLC5A2, MAPK4, MAPK3 | MAPK14 53/4885PRKD3 232/4885MAP4K4 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.