Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4585816 | 1.00 | MEN1 (0.37) | MEN1KMT2ASMN1; SMN2ALDH1A1GAA | |
| Trifluoroacetic Acid SCHEMBL4585709 | 0.93 | ENPP2 (0.39) | MEN1KMT2AALDH1A1MAPTBRAF | |
| Trifluoroacetic Acid SCHEMBL4585722 | 0.93 | ENPP2 (0.39) | MEN1KMT2AALDH1A1MAPTBRAF | |
| Trifluoroacetic Acid SCHEMBL2990672 | 0.92 | MAPT (0.43) | MEN1KMT2ASMN1; SMN2ALDH1A1GAA | |
| Trifluoroacetic Acid SCHEMBL5048576 | 0.92 | MAPT (0.43) | MEN1KMT2ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL4585828 | 0.91 | GAA (0.35) | MEN1KMT2ASMN1; SMN2ALDH1A1GAA | |
| Trifluoroacetic Acid SCHEMBL4586199 | 0.89 | GBA1 (0.39) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| Trifluoroacetic Acid SCHEMBL4586182 | 0.89 | GBA1 (0.39) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| Trifluoroacetic Acid SCHEMBL2996289 | 0.89 | BRAF (0.35) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| Trifluoroacetic Acid SCHEMBL2996297 | 0.89 | BRAF (0.35) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879563-A4 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1879563-A2 | NOVEL CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006132739-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-12-14 | — | — | WO | disclosed |