Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MC4R | P32245 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4585717 | 0.93 | MEN1 (0.38) | MEN1KMT2AALDH1A1BRAFLMNA | |
| Trifluoroacetic Acid SCHEMBL4585836 | 0.91 | MEN1 (0.37) | GAAMAPTMEN1KMT2ASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL4585816 | 0.91 | MEN1 (0.37) | GAAMAPTMEN1KMT2ASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL2990672 | 0.91 | MAPT (0.43) | GAAMAPTMEN1KMT2ASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5048576 | 0.91 | MAPT (0.43) | GAAMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4586191 | 0.89 | ALDH1A1 (0.37) | GAAMAPTMEN1KMT2AALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL5048553 | 0.84 | MEN1 (0.47) | GAAMAPTMEN1KMT2AALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL2988374 | 0.84 | MEN1 (0.47) | GAAMAPTMEN1KMT2AALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL4585709 | 0.84 | ENPP2 (0.39) | MAPTMEN1KMT2AALDH1A1BRAF | |
| Trifluoroacetic Acid SCHEMBL4585722 | 0.84 | ENPP2 (0.39) | MAPTMEN1KMT2AALDH1A1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879563-A4 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1879563-A2 | NOVEL CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006132739-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-12-14 | — | — | WO | disclosed |