Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 5/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | MELK | Q14680 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4586074 | 1.00 | CISD1 (0.40) | CISD1EGFRPOLBENPP2MEN1 | |
| SCHEMBL2993653 | 0.89 | GAA (0.44) | CISD1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL5049846 | 0.89 | GAA (0.44) | CISD1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL4585695 | 0.88 | CISD1 (0.41) | CISD1EGFRPOLBENPP2MEN1 | |
| SCHEMBL4585691 | 0.88 | CISD1 (0.41) | CISD1EGFRPOLBENPP2MEN1 | |
| SCHEMBL4586124 | 0.84 | ENPP2 (0.45) | CISD1ENPP2MEN1KMT2ACSF1R | |
| SCHEMBL2993654 | 0.83 | CISD1 (0.38) | CISD1POLBENPP2MEN1KMT2A | |
| SCHEMBL4585835 | 0.82 | MEN1 (0.47) | CISD1POLBENPP2MEN1KMT2A | |
| SCHEMBL4585846 | 0.82 | MEN1 (0.47) | CISD1POLBENPP2MEN1KMT2A | |
| SCHEMBL4605704 | 0.81 | CISD1 (0.41) | CISD1EGFRPOLBENPP2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879563-A4 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1879563-A2 | NOVEL CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006132739-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-12-14 | — | — | WO | disclosed |