Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.71 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.71 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.42 |
| ▸ | FPR2 | P25090 | 6/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4586009 | 0.93 | MEN1 (0.82) | PDE4APDE4DMEN1KMT2ACHRM1 | |
| SCHEMBL3247339 | 0.93 | MEN1 (0.82) | PDE4APDE4DMEN1KMT2ACHRM1 | |
| SCHEMBL4585220 | 0.93 | MEN1 (0.82) | PDE4APDE4DMEN1KMT2ACHRM1 | |
| SCHEMBL6858437 | 0.91 | MEN1 (0.74) | PDE4APDE4DMEN1KMT2ACHRM1 | |
| SCHEMBL7441633 | 0.91 | MEN1 (0.74) | PDE4APDE4DMEN1KMT2ACHRM1 | |
| SCHEMBL3234167 | 0.91 | MEN1 (0.74) | PDE4APDE4DMEN1KMT2ACHRM1 | |
| SCHEMBL5494252 | 0.91 | MEN1 (0.74) | PDE4APDE4DMEN1KMT2ACHRM1 | |
| SCHEMBL5424919 | 0.90 | PDE4A (0.88) | PDE4APDE4DMEN1KMT2ACHRM1 | |
| SCHEMBL7434908 | 0.90 | PDE4A (0.88) | PDE4APDE4DMEN1KMT2ACHRM1 | |
| SCHEMBL5425481 | 0.90 | PDE4A (0.88) | PDE4APDE4DMEN1KMT2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575521-A4 | PHARMACEUTICAL COMPOSITION OF 1-(3-HYDROXY-4-METHOXYPHENYL)-4-METHYL-5-ETHYL-7,8-DIMETHOXY-5H-2,3-BENZODIAZEPINE AND USES THEROF | VELA ACQUISITION CORP (US) | 2008-04-30 | — | — | EP | claimed |
| EP-1575521-A2 | PHARMACEUTICAL COMPOSITION OF 1-(3-HYDROXY-4-METHOXYPHENYL)-4-METHYL-5-ETHYL-7,8-DIMETHOXY-5H-2,3-BENZODIAZEPINE AND USES THEROF | Vela Pharmaceuticals Inc. (US) | 2005-09-21 | — | — | EP | claimed |
| WO-2004069155-A2 | PHARMACEUTICAL COMPOSITION OF 1-(3-HYDROXY-4-METHOXYPHENYL)-4-METHYL-5-ETHYL-7,8-DIMETHOXY-5H-2,3-BENZODIAZEPINE AND USES THEROF | VELA PHARMACEUTICALS, INC. (US) | 2004-08-19 | — | — | WO | claimed |