Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.82 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.82 |
| ▸ | PDE4A | P27815 | 1/20 | 0.82 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.82 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.82 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.36 |
| ▸ | TUBB | P07437 | 4/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4585220 | 1.00 | MEN1 (0.82) | MEN1KMT2ACHRM1PDE4APDE4D | |
| SCHEMBL3247339 | 1.00 | MEN1 (0.82) | MEN1KMT2ACHRM1PDE4APDE4D | |
| SCHEMBL6858437 | 0.95 | MEN1 (0.74) | MEN1KMT2ACHRM1PDE4APDE4D | |
| SCHEMBL5494252 | 0.95 | MEN1 (0.74) | MEN1KMT2ACHRM1PDE4APDE4D | |
| SCHEMBL3234167 | 0.95 | MEN1 (0.74) | MEN1KMT2ACHRM1PDE4APDE4D | |
| SCHEMBL7441633 | 0.95 | MEN1 (0.74) | MEN1KMT2ACHRM1PDE4APDE4D | |
| SCHEMBL4586153 | 0.93 | PDE4A (0.71) | MEN1KMT2ACHRM1PDE4APDE4D | |
| SCHEMBL4593681 | 0.92 | MEN1 (0.73) | MEN1KMT2ACHRM1PDE4APDE4D | |
| SCHEMBL5426502 | 0.92 | MEN1 (0.84) | MEN1KMT2ACHRM1PDE4APDE4D | |
| SCHEMBL4307435 | 0.92 | MEN1 (0.84) | MEN1KMT2ACHRM1PDE4APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040254173-A1 | Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines | VELA ACQUISITION CORPORATION | 2004-12-16 | — | — | US | claimed |
| US-20040229866-A1 | Method of lowering body temperature with (S)-2,3-benzodiazepines | VELA PHARMACEUTICALS, INC. | 2004-11-18 | — | — | US | claimed |
| WO-2004073638-A2 | METHOD OF LOWERING BODY TEMPERATURE WITH (S)-2,3-BENZODIAZEPINES | VELA PHARMACEUTICALS, INC. (US) | 2004-09-02 | — | — | WO | claimed |
| US-20040152695-A1 | Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine and uses thereof | VELA PHARMACEUTICALS, INC. | 2004-08-05 | — | — | US | claimed |
| EP-1575521-A4 | PHARMACEUTICAL COMPOSITION OF 1-(3-HYDROXY-4-METHOXYPHENYL)-4-METHYL-5-ETHYL-7,8-DIMETHOXY-5H-2,3-BENZODIAZEPINE AND USES THEROF | VELA ACQUISITION CORP (US) | 2008-04-30 | — | — | EP | disclosed |
| EP-1575521-A2 | PHARMACEUTICAL COMPOSITION OF 1-(3-HYDROXY-4-METHOXYPHENYL)-4-METHYL-5-ETHYL-7,8-DIMETHOXY-5H-2,3-BENZODIAZEPINE AND USES THEROF | Vela Pharmaceuticals Inc. (US) | 2005-09-21 | — | — | EP | disclosed |
| US-20040254173-A1 | Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines | VELA ACQUISITION CORPORATION | 2004-12-16 | — | — | US | disclosed |
| US-20040229866-A1 | Method of lowering body temperature with (S)-2,3-benzodiazepines | VELA PHARMACEUTICALS, INC. | 2004-11-18 | — | — | US | disclosed |
| WO-2004069155-A2 | PHARMACEUTICAL COMPOSITION OF 1-(3-HYDROXY-4-METHOXYPHENYL)-4-METHYL-5-ETHYL-7,8-DIMETHOXY-5H-2,3-BENZODIAZEPINE AND USES THEROF | VELA PHARMACEUTICALS, INC. (US) | 2004-08-19 | — | — | WO | disclosed |
| US-20040152695-A1 | Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine and uses thereof | VELA PHARMACEUTICALS, INC. | 2004-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229866-A1 | Method of lowering body temperature with (S)-2,3-benzodiazepines | CYP11B2, CYP2S1, CYP1A2 | MEN1 2972/4885KMT2A 2209/4885CHRM1 700/4885 |
| US-20040152695-A1 | Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine and uses thereof | GABRA4, GABRA2, GABRB2 | MEN1 3817/4885KMT2A 368/4885CHRM1 630/4885 |
| US-20040254173-A1 | Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines | DRD2, OPRD1, DRD1 | MEN1 4311/4885KMT2A 2610/4885CHRM1 80/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.