SCHEMBL4586500

SCHEMBL4586500

Cc1cc(C)c(C([SiH2]Cl)c2c(C)cc(C)cc2C)c(C)c1

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 4/20 0.35
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
LMNA P02545 1/20 0.30
GAA P10253 1/20 0.30
MAPT P10636 1/20 0.30
SLC6A2 P23975 1/20 0.30
SLC6A4 P31645 1/20 0.30
SLC6A3 Q01959 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1315475 0.82 SLC6A2 (0.44) RAPGEF4ALDH1A1LMNAMAPTSLC6A2
SCHEMBL2848311 0.75 RAPGEF4 (0.43) RAPGEF4KDM4EALDH1A1LMNAGAA
SCHEMBL1636181 0.70 RAPGEF4 (0.39) RAPGEF4KDM4EALDH1A1LMNAGAA
SCHEMBL7705523 0.70 RAPGEF4 (0.39) RAPGEF4KDM4EALDH1A1LMNAGAA
SCHEMBL29613032 0.69 RAPGEF4 (0.38) RAPGEF4KDM4EALDH1A1LMNAGAA
SCHEMBL18567679 0.69 RAPGEF4 (0.43) RAPGEF4KDM4EALDH1A1LMNAGAA
SCHEMBL27927634 0.67 RAPGEF4 (0.41) RAPGEF4KDM4EALDH1A1LMNAGAA
SCHEMBL5163137 0.67 RAPGEF4 (0.41) RAPGEF4KDM4EALDH1A1LMNAGAA
SCHEMBL22298450 0.67 SLC6A2 (0.38) RAPGEF4KDM4EALDH1A1LMNAGAA
SCHEMBL21259500 0.67 SLC6A2 (0.38) RAPGEF4KDM4EALDH1A1LMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7365198-B2 Silyl compound, light emitting material, and organic light emitting device using the same CANON KABUSHIKI KAISHA (JP) 2008-04-29 US disclosed
US-20070205715-A1 SILYL COMPOUND, LIGHT EMITTING MATERIAL, AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME CANON KABUSHIKI KAISHA (JP) 2007-09-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070205715-A1 SILYL COMPOUND, LIGHT EMITTING MATERIAL, AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME LAS1L, CCNL2, EML4 RAPGEF4 4457/4885KDM4E 1577/4885ALDH1A1 305/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.