Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | EYA2 | O00167 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | MVD | P53602 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14409182 | 0.80 | TDP1 (0.35) | TDP1EYA2APPACEMVD | |
| SCHEMBL1597034 | 0.78 | — | — | |
| SCHEMBL9214812 | 0.77 | TDP1 (0.36) | TDP1EYA2APPACEMVD | |
| SCHEMBL321404 | 0.76 | TDP1 (0.39) | TDP1EYA2APPACELMNA | |
| Methyl Alcohol SCHEMBL3155059 | 0.76 | CHRM1 (0.41) | TDP1EYA2APPACEMVD | |
| SCHEMBL11293864 | 0.75 | TDP1 (0.35) | TDP1EYA2APPACEMVD | |
| SCHEMBL112280 | 0.75 | — | — | |
| SCHEMBL9216352 | 0.74 | — | — | |
| SCHEMBL22540356 | 0.74 | — | — | |
| SCHEMBL12521172 | 0.73 | EGLN1 (0.40) | TDP1EYA2APPACEMVD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221836-B1 | Composition of pyruvate and anabolic protein and method for increasing fat loss in a mammal | PAXTON KING BEALE | 2001-04-24 | — | — | US | claimed |
| US-6008252-A | Method for increasing muscle mass in a mammal | BEALE PAXTON K (US) | 1999-12-28 | — | — | US | claimed |
| US-5919767-A | ADJUST PROTEIN CONCNETRATION IN MUSCLES | PAX BEALE AND SOPHIE TAGGART TRUST DATED AUGUST 26, 1997, THE | 1999-07-06 | — | — | US | claimed |
| EP-0914109-A1 | COMPOSITION OF PYRUVATE AND PROTEIN AND METHOD FOR INCREASING PROTEIN CONCENTRATION IN A MAMMAL | Beale, Paxton K. (US) | 1999-05-12 | — | — | EP | claimed |
| EP-0914108-A1 | COMPOSITION OF PYRUVATE AND ANTI-CORTISOL COMPOUNDS AND METHOD FOR INCREASING PROTEIN CONCENTRATION IN A MAMMAL | Beale, Paxton K. (US) | 1999-05-12 | — | — | EP | claimed |
| US-5756469-A | SYNERGISTIC COMPOSITION FOR ENTERIC ADMINISTRATION | PAX BEALE AND SOPHIE TAGGART TRUST DATED AUGUST 26, 1997, THE | 1998-05-26 | — | — | US | claimed |
| US-5716926-A | ENHANCING THE PHYSICAL ENDURANCE OF MAMMAL BY ADMINISTERING TO MAMMAL THE ANABOLIC PROTEIN AND PYRUVATE | Beale, Paxton K. (US) | 1998-02-10 | — | — | US | claimed |
| WO-1998004254-A1 | COMPOSITION OF PYRUVATE AND PROTEIN AND METHOD FOR INCREASING PROTEIN CONCENTRATION IN A MAMMAL | BEALE PAXTON K (US) | 1998-02-05 | — | — | WO | claimed |
| WO-1998004253-A1 | COMPOSITION OF PYRUVATE AND ANTI-CORTISOL COMPOUNDS AND METHOD FOR INCREASING PROTEIN CONCENTRATION IN A MAMMAL | BEALE PAXTON K (US) | 1998-02-05 | — | — | WO | claimed |
| US-20080293702-A1 | Nitric Oxide Enhancing Pyruvate Compounds, Compositions and Methods of Use | NITROMED, INC. (US) | 2008-11-27 | — | — | US | disclosed |
| US-20080287407-A1 | Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use | NITROMED, INC. (US) | 2008-11-20 | — | — | US | disclosed |
| EP-1692107-A4 | NITRIC OXIDE RELEASING PYRUVATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | NITROMED INC (US) | 2008-10-29 | — | — | EP | disclosed |
| EP-1971340-A2 | NITRIC OXIDE ENHANCING PYRUVATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Nitromed, Inc. (US) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007117180-A1 | AZAHETEROCYCLES, COMBINATORY LIBRARY, FOCUSED LIBRARY, PHARMACEUTICAL COMPOSITION AND METHODS FOR THE PRODUCTION THEREOF | 'CHEMICAL DIVERSITY RESEARCH INSTITUTE' LTD. (RU) | 2007-10-18 | — | — | WO | disclosed |
| US-5472980-A | Reducing insulin resistance in mammals with amino acid derivatives | ABBOTT LABORATORIES (US) | 1995-12-05 | — | — | US | disclosed |
| EP-0636117-A1 | USE OF PYRUVAMIDE AND SELECTED PYRUVYL-AMINO ACIDS | ABBOTT LABORATORIES (US) | 1995-02-01 | — | — | EP | disclosed |
| US-5312985-A | Reaction of sodium pyruvate with thionyl chloride and oxalyl chloride to form pyruvyl chloride, then reaction with 1,1,1,3,3,3-hexamethyldisilazane and methanol to form pyruvamide | ABBOTT LABORATORIES (US) | 1994-05-17 | — | — | US | disclosed |
| US-5283260-A | Oral ingesting a pyruvyl-amino acid compound before a glucose tolerance test | ABBOTT LABORATORIES (US) | 1994-02-01 | — | — | US | disclosed |
| WO-1993021147-A1 | METHOD OF ADMINISTERING PYRUVATE AND METHODS OF SYNTHESIZING PYRUVATE PRECURSORS | ABBOTT LABORATORIES (US) | 1993-10-28 | — | — | WO | disclosed |
| US-5256697-A | Covalently linked pyruvyl-amino compound | ABBOTT LABORATORIES | 1993-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293702-A1 | Nitric Oxide Enhancing Pyruvate Compounds, Compositions and Methods of Use | PC, PDK1, NOS3 | TDP1 2486/4885EYA2 1134/4885APP 1377/4885 |
| US-20080287407-A1 | Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use | PC, PDK1, NOS3 | TDP1 501/4885EYA2 1919/4885APP 2378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.