Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.41 |
| ▸ | GCGR | P47871 | 3/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4585823 | 0.89 | PTGS1 (0.46) | ALDH1A1MAPK1MAPTRAB9AKDM4E | |
| SCHEMBL4586818 | 0.83 | KMT2A (0.39) | ALDH1A1MAPK1MAPK14MAPTNPC1 | |
| SCHEMBL4586151 | 0.81 | ALDH1A1 (0.53) | ALDH1A1MAPK1MAPTNPC1RAB9A | |
| SCHEMBL4587169 | 0.80 | PTGS2 (0.47) | PTGS1PTGS2 | |
| SCHEMBL4586810 | 0.80 | ALDH1A1 (0.42) | ALDH1A1MAPK1MAPK13GCGRMAPK12 | |
| SCHEMBL4586952 | 0.79 | PTGS2 (0.56) | ADORA1PTGS1PTGS2LMNA | |
| SCHEMBL4587361 | 0.78 | PTGS2 (0.53) | PTGS1PTGS2 | |
| SCHEMBL4587022 | 0.78 | PTGS2 (0.40) | MAPTPTGS2TP53GRM5GRM1 | |
| SCHEMBL4587680 | 0.77 | PTGS2 (0.59) | ADORA1PTGS1PTGS2LMNA | |
| SCHEMBL19053583 | 0.72 | GRM1 (0.44) | ALDH1A1MAPK1MAPTRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556364-A4 | ISOTHIAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME | CJ CORP (KR) | 2008-04-16 | — | — | EP | disclosed |
| CN-100357282-C | Isothiazole derivatives, process for the preparation thereof, and pharmaceutical composition including the same | CJ CORP (KR) | 2007-12-26 | — | — | CN | disclosed |
| CN-1705650-A | Isothiazole derivatives, process for preparing the same, and pharmaceutical composition comprising the same | CJ CORP (KR) | 2005-12-07 | — | — | CN | disclosed |
| US-6967213-B2 | Isothiazole derivatives, process for the preparation thereof, and pharmaceutical composition including the same | CJ CORP. (KR) | 2005-11-22 | — | — | US | disclosed |
| EP-1556364-A1 | ISOTHIAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME | CJ Corp. (KR) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004035553-A1 | ISOTHIAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME | CJ CORP. (KR) | 2004-04-29 | — | — | WO | disclosed |
| US-20040072884-A1 | Isothiazole derivatives, process for the preparation thereof, and pharmaceutical composition including the same | CJ CORP. (KR) | 2004-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040072884-A1 | Isothiazole derivatives, process for the preparation thereof, and pharmaceutical composition including the same | CYP3A5, CYP2C9, CYP2C19 | ALDH1A1 166/4885MAPK1 289/4885MAPK13 989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.