Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12854132 | 0.89 | CYP11B1 (0.41) | CYP11B1CYP11B2ALOX15ALDH1A1HPGD | |
| SCHEMBL10166454 | 0.76 | CYP2A6 (0.47) | CYP11B1CYP11B2ALOX15CYP2A6CYP2B6 | |
| SCHEMBL28013350 | 0.76 | CYP11B1 (0.41) | CYP11B1CYP11B2ALOX15ALDH1A1HPGD | |
| SCHEMBL3403280 | 0.76 | CYP11B1 (0.41) | CYP11B1CYP11B2ALOX15ALDH1A1HPGD | |
| SCHEMBL27304439 | 0.76 | CYP11B1 (0.41) | CYP11B1CYP11B2ALOX15ALDH1A1HPGD | |
| SCHEMBL28020956 | 0.76 | CYP11B1 (0.41) | CYP11B1CYP11B2ALOX15ALDH1A1HPGD | |
| SCHEMBL6739617 | 0.76 | ALDH1A1 (0.42) | CYP11B1CYP11B2ALOX15ALDH1A1HPGD | |
| SCHEMBL10166456 | 0.76 | CYP11B1 (0.46) | CYP11B1CYP11B2ALOX15CYP2A6CYP2B6 | |
| SCHEMBL28957794 | 0.76 | CYP11B1 (0.41) | CYP11B1CYP11B2ALOX15ALDH1A1HPGD | |
| SCHEMBL27862904 | 0.76 | ALDH1A1 (0.42) | CYP11B1CYP11B2ALOX15CYP2A6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556364-A4 | ISOTHIAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME | CJ CORP (KR) | 2008-04-16 | — | — | EP | disclosed |
| EP-1556364-A1 | ISOTHIAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME | CJ Corp. (KR) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004035553-A1 | ISOTHIAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME | CJ CORP. (KR) | 2004-04-29 | — | — | WO | disclosed |