Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11107027 | 0.79 | CYP2A6 (0.48) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL4587159 | 0.76 | CYP11B1 (0.42) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL28020956 | 0.74 | CYP11B1 (0.41) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL27862904 | 0.74 | ALDH1A1 (0.42) | ALDH1A1CYP1A2KDM4ESMN1; SMN2LMNA | |
| SCHEMBL27304439 | 0.74 | CYP11B1 (0.41) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL28013350 | 0.74 | CYP11B1 (0.41) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL28957794 | 0.74 | CYP11B1 (0.41) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL11431701 | 0.71 | BCAT2 (0.47) | ALDH1A1KDM4ENPC1RAB9AGAA | |
| SCHEMBL5154806 | 0.69 | LMNA (0.45) | ALDH1A1MAPTKDM4ESMN1; SMN2LMNA | |
| SCHEMBL11550969 | 0.69 | ALDH1A1 (0.43) | ALDH1A1KDM4ESMN1; SMN2LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641852-B | Sulfonamides as GPR 40-and GPR 120-agonists | 东佩制药股份公司 | 2022-08-26 | — | — | CN | disclosed |
| EP-3497085-B1 | SULFONAMIDES AS GPR40- AND GPR120-AGONISTS | DOMPE FARM SPA (IT) | 2020-07-22 | — | — | EP | disclosed |
| EP-3497085-A1 | SULFONAMIDES AS GPR40- AND GPR120-AGONISTS | Dompé farmaceutici S.p.A. (IT) | 2019-06-19 | — | — | EP | disclosed |
| US-20190169142-A1 | SULFONAMIDES AS GPR40- AND GPR120-AGONISTS | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2019-06-06 | — | — | US | disclosed |
| CN-109641852-A | Sulfonamides as GPR 40-and GPR 120-agonists | 东佩制药股份公司 | 2019-04-16 | — | — | CN | disclosed |
| WO-2018029150-A1 | SULFONAMIDES AS GPR40- AND GPR120-AGONISTS | DOMPE' FARMACEUTICI S.P.A. (IT) | 2018-02-15 | — | — | WO | disclosed |
| EP-3281937-A1 | SULFONAMIDES AS GPR40- AND GPR120-AGONISTS | Dompé farmaceutici S.p.A. (IT) | 2018-02-14 | — | — | EP | disclosed |
| US-20040023807-A1 | 3-Arylisothiazoles and their use as herbicides | BASF AKTIENGESELLSCHAFT (DE) | 2004-02-05 | — | — | US | disclosed |
| EP-1289970-A1 | 3-ARYLISOTHIAZOLES AND THEIR USE AS HERBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001087863-A1 | 3-ARYLISOTHIAZOLES AND THEIR USE AS HERBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 2001-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040023807-A1 | 3-Arylisothiazoles and their use as herbicides | DDT, HAX1, SULT1E1 | ALDH1A1 142/4885MAPT 2566/4885CYP1A2 90/4885 |
| US-20190169142-A1 | SULFONAMIDES AS GPR40- AND GPR120-AGONISTS | GPR119, GPR88, GPR84 | ALDH1A1 3932/4885MAPT 4139/4885CYP1A2 1435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.