Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4587159 | 0.76 | CYP11B1 (0.42) | CYP11B1CYP11B2MEN1KMT2ABACE1 | |
| SCHEMBL27862904 | 0.74 | ALDH1A1 (0.42) | CYP11B1CYP11B2L3MBTL1MEN1KMT2A | |
| SCHEMBL6739617 | 0.74 | ALDH1A1 (0.42) | CYP11B1CYP11B2MEN1KMT2AALDH1A1 | |
| SCHEMBL28020956 | 0.74 | CYP11B1 (0.41) | CYP11B1CYP11B2L3MBTL1MEN1KMT2A | |
| SCHEMBL28957794 | 0.74 | CYP11B1 (0.41) | CYP11B1CYP11B2L3MBTL1MEN1KMT2A | |
| SCHEMBL27304439 | 0.74 | CYP11B1 (0.41) | CYP11B1CYP11B2L3MBTL1MEN1KMT2A | |
| SCHEMBL28013350 | 0.74 | CYP11B1 (0.41) | CYP11B1CYP11B2MEN1KMT2AALDH1A1 | |
| SCHEMBL11550969 | 0.74 | ALDH1A1 (0.43) | CYP11B1CYP11B2L3MBTL1MEN1KMT2A | |
| SCHEMBL31526173 | 0.74 | CYP11B1 (0.53) | CYP11B1CYP11B2MEN1KMT2AALDH1A1 | |
| SCHEMBL9675192 | 0.74 | CYP11B1 (0.53) | CYP11B1CYP11B2L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252619-A1 | ISOTHIAZOLE-PYRIDINE DERIVATIVES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY | Fibrogen, Inc. (US) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009089547-A1 | ISOTHIAZOLE-PYRIDINE DERIVATIVES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY | FIBROGEN, INC. (US) | 2009-07-16 | — | — | WO | disclosed |