Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.47 |
| ▸ | HTR1A | P08908 | 4/20 | 0.46 |
| ▸ | HTR1D | P28221 | 4/20 | 0.46 |
| ▸ | HTR1B | P28222 | 4/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 4/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 3/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 2/20 | 0.38 |
| ▸ | CLK2 | P49760 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2993532 | 1.00 | HTR6 (0.47) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL2993529 | 1.00 | HTR6 (0.47) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL4585273 | 0.92 | KMT2A (0.41) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL2995679 | 0.92 | KMT2A (0.41) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL2995682 | 0.92 | KMT2A (0.41) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL4586479 | 0.91 | KMT2A (0.41) | HTR6PIM1CLK1CLK2DYRK1A | |
| SCHEMBL4586474 | 0.91 | KMT2A (0.41) | HTR6PIM1CLK1CLK2DYRK1A | |
| SCHEMBL2996092 | 0.90 | ENPP2 (0.48) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL2996088 | 0.90 | ENPP2 (0.48) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL2993546 | 0.90 | MEN1 (0.40) | HTR6HTR1AHTR1DHTR1BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879563-A4 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-07-16 | — | — | EP | claimed |
| EP-1879563-A2 | NOVEL CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-01-23 | — | — | EP | claimed |
| WO-2006132739-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-12-14 | — | — | WO | claimed |
| EP-1879563-A4 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1879563-A2 | NOVEL CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006132739-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-12-14 | — | — | WO | disclosed |