Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3544754 | 0.94 | SIGMAR1 (0.45) | SIGMAR1MAOA | |
| SCHEMBL9871271 | 0.85 | EPHX1 (0.50) | SIGMAR1MAOA | |
| SCHEMBL6049243 | 0.81 | EPHX1 (0.50) | SIGMAR1MAOA | |
| SCHEMBL11693551 | 0.81 | TRPA1 (0.46) | SIGMAR1PPARGPPARA | |
| SCHEMBL8824531 | 0.80 | SIGMAR1 (0.45) | SIGMAR1MAOA | |
| SCHEMBL7929689 | 0.80 | CSNK1E (0.54) | — | |
| SCHEMBL8673059 | 0.78 | EPHX1 (0.43) | SIGMAR1MAOA | |
| SCHEMBL24108632 | 0.74 | EPHX1 (0.48) | SIGMAR1MAOA | |
| SCHEMBL7085691 | 0.74 | EPHX1 (0.48) | SIGMAR1MAOA | |
| SCHEMBL4423916 | 0.74 | SIGMAR1 (0.44) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375098-B2 | 8β-vinyl-11β-(ω-substituted)alkyl-estra-1,3,5(10)-trienes | SCHERING A.G. (DE) | 2008-05-20 | — | — | US | disclosed |
| EP-1622924-A2 | 8$G(B)-VINYL-11$G(B)-( G(V)-SUBSTITUTED)ALKYL-ESTRA-1,3,5(10)-TRIENES | Schering Aktiengesellschaft (DE) | 2006-02-08 | — | — | EP | disclosed |
| US-20050065135-A1 | 8beta-Vinyl-11beta-(omega-substituted)alkyl-estra-1,3,5(10)-trienes | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-03-24 | — | — | US | disclosed |
| US-20050043314-A1 | Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same | EGIS GYOGYSZERGYAR RT. (HU) | 2005-02-24 | — | — | US | disclosed |
| WO-2004094451-A2 | 8$G(B)-VINYL-11$G(B)-($G(V)-SUBSTITUTED)ALKYL-ESTRA-1,3,5(10)-TRIENES | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-11-04 | — | — | WO | disclosed |
| WO-2003043983-A1 | PIPERAZINE DERIVATIVES DESTABILISING ANDROGEN RECEPTORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043314-A1 | Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same | CYP2C19, CYP2D6, CYP3A5 | SIGMAR1 220/4885PPARG 433/4885PPARA 718/4885 |
| US-20050065135-A1 | 8beta-Vinyl-11beta-(omega-substituted)alkyl-estra-1,3,5(10)-trienes | CYP19A1, HSD17B11, ESR2 | SIGMAR1 1265/4885PPARG 152/4885PPARA 101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.