Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.54 |
| ▸ | KDR | P35968 | 8/20 | 0.52 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592898 | 0.89 | KDR (0.51) | GPR119KDRTBK1 | |
| SCHEMBL4593297 | 0.88 | GPR119 (0.52) | GPR119KDRIKBKETBK1 | |
| SCHEMBL4594266 | 0.84 | KDR (0.52) | GPR119KDR | |
| SCHEMBL4587627 | 0.81 | KDR (0.49) | KDR | |
| SCHEMBL389261 | 0.81 | GPR119 (0.61) | GPR119IKBKETBK1 | |
| SCHEMBL390031 | 0.79 | GPR119 (0.54) | GPR119IKBKETBK1 | |
| SCHEMBL385936 | 0.78 | GPR119 (0.50) | GPR119KDRIKBKETBK1 | |
| SCHEMBL4594092 | 0.78 | NSD2 (0.49) | GPR119KDR | |
| SCHEMBL4586120 | 0.77 | KDR (0.60) | KDR | |
| SCHEMBL389525 | 0.77 | GPR119 (0.50) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558609-A4 | KINASE INHIBITORS | MERCK & CO INC (US) | 2008-05-28 | — | — | EP | claimed |
| EP-1558609-A2 | KINASE INHIBITORS | Merck & Co., Inc. (US) | 2005-08-03 | — | — | EP | claimed |
| WO-2004041164-A2 | KINASE INHIBITORS | MERCK & CO., INC. (US) | 2004-05-21 | — | — | WO | claimed |
| EP-1558609-A4 | KINASE INHIBITORS | MERCK & CO INC (US) | 2008-05-28 | — | — | EP | disclosed |
| EP-1558609-A2 | KINASE INHIBITORS | Merck & Co., Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004041164-A2 | KINASE INHIBITORS | MERCK & CO., INC. (US) | 2004-05-21 | — | — | WO | disclosed |