Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4587631 | 0.89 | GPR119 (0.54) | KDRGPR119TBK1 | |
| SCHEMBL4593791 | 0.84 | KDR (0.46) | KDRGPR119TBK1 | |
| SCHEMBL4594266 | 0.84 | KDR (0.52) | KDRGPR119 | |
| SCHEMBL7228109 | 0.81 | KDR (0.56) | KDRGPR119TBK1 | |
| SCHEMBL4593297 | 0.79 | GPR119 (0.52) | KDRGPR119TBK1 | |
| SCHEMBL4594092 | 0.77 | NSD2 (0.49) | KDRGPR119 | |
| SCHEMBL1817410 | 0.75 | KDR (0.42) | KDRGPR119 | |
| SCHEMBL1815909 | 0.73 | KDR (0.51) | KDRGPR119TBK1 | |
| SCHEMBL4587627 | 0.72 | KDR (0.49) | KDR | |
| SCHEMBL4586816 | 0.72 | KDR (0.39) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558609-A4 | KINASE INHIBITORS | MERCK & CO INC (US) | 2008-05-28 | — | — | EP | disclosed |
| EP-1558609-A2 | KINASE INHIBITORS | Merck & Co., Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004041164-A2 | KINASE INHIBITORS | MERCK & CO., INC. (US) | 2004-05-21 | — | — | WO | disclosed |