Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 2/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.46 |
| ▸ | KDR | P35968 | 6/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4593297 | 0.86 | GPR119 (0.52) | NSD2GPR119KDR | |
| SCHEMBL4594091 | 0.80 | KDR (0.43) | KDR | |
| SCHEMBL1817410 | 0.79 | KDR (0.42) | NSD2GPR119KDR | |
| SCHEMBL4594266 | 0.78 | KDR (0.52) | GPR119KDR | |
| SCHEMBL4587631 | 0.78 | GPR119 (0.54) | GPR119KDR | |
| SCHEMBL4594057 | 0.77 | KDR (0.49) | NSD2KDR | |
| SCHEMBL4585902 | 0.77 | KDR (0.45) | NSD2KDR | |
| SCHEMBL4592898 | 0.77 | KDR (0.51) | GPR119KDR | |
| SCHEMBL1815909 | 0.77 | KDR (0.51) | NSD2GPR119KDR | |
| SCHEMBL30329928 | 0.75 | ALDH1A1 (0.53) | NSD2GPR119SYKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558609-A4 | KINASE INHIBITORS | MERCK & CO INC (US) | 2008-05-28 | — | — | EP | disclosed |
| EP-1558609-A2 | KINASE INHIBITORS | Merck & Co., Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004041164-A2 | KINASE INHIBITORS | MERCK & CO., INC. (US) | 2004-05-21 | — | — | WO | disclosed |