Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.53 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 6/20 | 0.48 |
| ▸ | CA2 | P00918 | 6/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.45 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4588604 | 0.83 | LOXL2 (0.56) | LOXL2CYP4A11CA1CA2CYP4F2 | |
| SCHEMBL4589135 | 0.83 | LOXL2 (0.56) | LOXL2CYP4A11CA1CA2CYP4F2 | |
| SCHEMBL4587583 | 0.83 | ALDH1A1 (0.48) | MEN1KMT2AMAPTTDP1 | |
| SCHEMBL5177723 | 0.80 | LOXL2 (0.59) | LOXL2CYP4A11CA1CA2CYP4F2 | |
| SCHEMBL10777253 | 0.78 | LOXL2 (0.58) | LOXL2CYP4A11CA1CA2CYP4F2 | |
| SCHEMBL24988006 | 0.78 | NPC1 (0.50) | MEN1KMT2AMAPK1 | |
| SCHEMBL3156555 | 0.78 | NPC1 (0.50) | MEN1KMT2AMAPK1 | |
| SCHEMBL15772079 | 0.78 | LOXL2 (0.61) | LOXL2CYP4A11CA1CA2CYP4F2 | |
| SCHEMBL25440208 | 0.78 | NPC1 (0.50) | MEN1KMT2AMAPK1 | |
| SCHEMBL765010 | 0.78 | LOXL2 (0.61) | LOXL2CYP4A11CA1CA2CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973405-A2 | HYDROXYALKYLARYLAMIDE DERIVATIVES | Merck & Co., Inc. (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007087130-A2 | HYDROXYALKYLARYLAMIDE DERIVATIVES | MERCK & CO., INC. (US) | 2007-08-02 | — | — | WO | disclosed |