Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | ANPEP | P15144 | 1/20 | 0.47 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25440208 | 0.84 | NPC1 (0.50) | KMT2ATSHRMEN1 | |
| SCHEMBL24988006 | 0.84 | NPC1 (0.50) | KMT2ATSHRMEN1 | |
| SCHEMBL3156555 | 0.84 | NPC1 (0.50) | KMT2ATSHRMEN1 | |
| SCHEMBL4587733 | 0.83 | LOXL2 (0.53) | KMT2ATDP1MEN1MAPT | |
| SCHEMBL22857534 | 0.83 | ACACB (0.49) | ALDH1A1ANPEPENPEPKMT2AADRB1 | |
| SCHEMBL6243190 | 0.80 | KDM6B (0.56) | ALDH1A1ANPEPENPEPKMT2AADRB1 | |
| SCHEMBL7299745 | 0.79 | MEN1 (0.51) | ALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7300551 | 0.79 | MEN1 (0.51) | ALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL28703199 | 0.79 | MEN1 (0.51) | ALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4598268 | 0.76 | ALDH1A1 (0.57) | ALDH1A1ANPEPENPEPKMT2AADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973405-A2 | HYDROXYALKYLARYLAMIDE DERIVATIVES | Merck & Co., Inc. (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007087130-A2 | HYDROXYALKYLARYLAMIDE DERIVATIVES | MERCK & CO., INC. (US) | 2007-08-02 | — | — | WO | disclosed |