Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.60 |
| ▸ | SLC5A1 | P13866 | 5/20 | 0.60 |
| ▸ | SLC5A2 | P31639 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | ELANE | P08246 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | CBS | P35520 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29150883 | 0.92 | ELANE (0.64) | GAASLC5A1SLC5A2MAPTELANE | |
| SCHEMBL29150893 | 0.90 | ELANE (0.68) | GAASLC5A1SLC5A2MAPTELANE | |
| SCHEMBL29150872 | 0.89 | SLC5A1 (0.65) | GAASLC5A1SLC5A2MAPTELANE | |
| SCHEMBL29150882 | 0.86 | ELANE (0.56) | GAASLC5A1SLC5A2MAPTELANE | |
| SCHEMBL29150900 | 0.85 | NFKB1 (0.67) | GAASLC5A1SLC5A2MAPTELANE | |
| Hydrochloric Acid SCHEMBL5209530 | 0.85 | ELANE (0.55) | GAASLC5A1SLC5A2MAPTELANE | |
| SCHEMBL29150901 | 0.80 | NFKB1 (0.59) | SLC5A1SLC5A2MAPTELANEALDH1A1 | |
| SCHEMBL459195 | 0.80 | ELANE (0.73) | GAASLC5A1SLC5A2MAPTELANE | |
| SCHEMBL27035891 | 0.79 | ELANE (0.88) | ELANEALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL27035935 | 0.79 | ELANE (0.88) | ELANEALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117143062-B | 4-Hydroxy-2-pyrone compound, preparation method and application | 西北农林科技大学 | 2024-09-20 | — | — | CN | disclosed |
| CN-117143062-A | 3-substituted 4-hydroxy-2-pyrone compound, preparation method and application | 西北农林科技大学 | 2023-12-01 | — | — | CN | disclosed |
| US-8772332-B2 | Arylpropionyl-alpha-pyrone antibacterial agents | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-07-08 | — | — | US | disclosed |
| US-20130296421-A1 | ARYLPROPIONYL-ALPHA-PYRONE ANTIBACTERIAL AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-11-07 | — | — | US | disclosed |
| WO-2012033815-A1 | ARYLPROPIONYL-ALPHA-PYRONE ANTIBACTERIAL AGENTS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2012-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130296421-A1 | ARYLPROPIONYL-ALPHA-PYRONE ANTIBACTERIAL AGENTS | QRFPR, MRPL21, BET1 | GAA 3805/4885SLC5A1 784/4885SLC5A2 1991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.