Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.65 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.53 |
| ▸ | RARA | P10276 | 1/20 | 0.53 |
| ▸ | RARB | P10826 | 1/20 | 0.53 |
| ▸ | RARG | P13631 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2681081 | 0.92 | GABRA2 (0.58) | SIRT2SIRT1HPGDALDH1A1MAPT | |
| SCHEMBL1078509 | 0.82 | TP53 (0.58) | SIRT2SIRT1HPGDALDH1A1MAPT | |
| SCHEMBL21760759 | 0.81 | SIRT2 (0.74) | SIRT2SIRT1HPGDHTTALDH1A1 | |
| SCHEMBL21749185 | 0.79 | SIRT2 (0.61) | SIRT2SIRT1HPGDHTTALDH1A1 | |
| SCHEMBL5783789 | 0.78 | ALDH1A1 (0.51) | HPGDALDH1A1MAPTGAAMEN1 | |
| SCHEMBL17414567 | 0.77 | KDM1A (0.54) | SIRT2SIRT1HPGDHTTALDH1A1 | |
| SCHEMBL6208711 | 0.76 | TP53 (0.51) | SIRT2SIRT1HPGDALDH1A1MAPT | |
| SCHEMBL24106782 | 0.75 | MEN1 (0.70) | ALDH1A1MAPTGAARARARARB | |
| SCHEMBL570961 | 0.75 | MEN1 (0.70) | ALDH1A1MAPTGAARARARARB | |
| SCHEMBL6444855 | 0.75 | SIRT2 (0.65) | SIRT2SIRT1HPGDHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080009506-A1 | Imidazole Compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-01-10 | — | — | US | disclosed |
| EP-1799650-A2 | IMIDAZOLE DERIVATIVES AS LARGE CONDUCTANCE CALCIUM ACTIVATED K CHANNEL OPENERS | TANABE SEIYAKU CO., LTD. (JP) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006030977-A2 | IMIDAZOLE DERIVATIVES AS LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENERS | TANABE SEIYAKU CO., LTD. (JP) | 2006-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009506-A1 | Imidazole Compound | KCNH2, KCNJ2, KCNH3 | SIRT2 1173/4885SIRT1 1155/4885HPGD 2560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.