Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1821353 | 0.84 | SLC6A2 (0.45) | SLC6A2SLC6A4ALDH1A1POLBLMNA | |
| SCHEMBL1818475 | 0.82 | POLB (0.46) | SLC6A2SLC6A4POLBLMNAKMT2A | |
| SCHEMBL11178102 | 0.78 | NPSR1 (0.44) | SLC6A2SLC6A4ALDH1A1POLBLMNA | |
| SCHEMBL11342769 | 0.78 | NPSR1 (0.44) | ALDH1A1POLBLMNATP53SMN1; SMN2 | |
| SCHEMBL755703 | 0.77 | ALDH1A1 (0.43) | SLC6A2SLC6A4ALDH1A1POLBLMNA | |
| SCHEMBL755702 | 0.77 | ALDH1A1 (0.43) | SLC6A2SLC6A4ALDH1A1POLBLMNA | |
| SCHEMBL10455652 | 0.77 | NPSR1 (0.43) | ALDH1A1POLBLMNATP53SMN1; SMN2 | |
| SCHEMBL10455650 | 0.77 | NPSR1 (0.43) | ALDH1A1POLBLMNATP53SMN1; SMN2 | |
| SCHEMBL11126728 | 0.76 | LMNA (0.47) | ALDH1A1POLBLMNATP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8226911 | 0.75 | ALDH1A1 (0.42) | SLC6A2SLC6A4ALDH1A1POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008100618-A2 | CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. (US) | 2008-08-21 | — | — | WO | disclosed |