Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | METTL3 | Q86U44 | 3/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4590290 | 0.87 | METTL3 (0.49) | METTL3EGLN1L3MBTL1NAMPTMAP3K5 | |
| SCHEMBL22529159 | 0.83 | METTL3 (0.51) | METTL3L3MBTL1NAMPTBRD4MAP3K5 | |
| SCHEMBL23950382 | 0.83 | KDM4E (0.54) | KDM4EPOLBGAARAB9ANPC1 | |
| SCHEMBL22499267 | 0.80 | METTL3 (0.50) | KDM4EMETTL3GAAL3MBTL1NAMPT | |
| SCHEMBL8608432 | 0.78 | KDM4E (0.63) | KDM4EPOLBEGLN1GAARAB9A | |
| SCHEMBL23534246 | 0.78 | KDM4E (0.56) | KDM4EPOLBGAARAB9ANPC1 | |
| SCHEMBL506759 | 0.78 | L3MBTL1 (0.47) | POLBGAAL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL31210837 | 0.78 | KDM4E (0.40) | KDM4EPOLBGAAALDH1A1HPGD | |
| SCHEMBL8866825 | 0.78 | ALDH1A1 (0.50) | KDM4EPOLBMETTL3GAARAB9A | |
| SCHEMBL25299622 | 0.77 | KDM4E (0.61) | KDM4EPOLBEGLN1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207650-A1 | Chemical Compounds 636 | ASTRAZENECA AB (SE) | 2008-08-28 | — | — | US | disclosed |
| US-20080207650-A1 | Chemical Compounds 636 | ASTRAZENECA AB (SE) | 2008-08-28 | — | — | US | disclosed |
| US-20080207650-A1 | Chemical Compounds 636 | ASTRAZENECA AB (SE) | 2008-08-28 | — | — | US | disclosed |
| WO-2008084240-A1 | CHEMICAL COMPOUNDS 636 : PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008084240-A1 | CHEMICAL COMPOUNDS 636 : PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207650-A1 | Chemical Compounds 636 | PDE4A, PDE3B, PDE3A | KDM4E 1450/4885POLB 1473/4885METTL3 4378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.