Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KCNJ1 | P48048 | 15/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19404141 | 0.81 | HSD17B10 (0.35) | NPC1RAB9AL3MBTL1KCNJ1SMN1; SMN2 | |
| SCHEMBL247419 | 0.75 | L3MBTL1 (0.36) | NPC1RAB9AL3MBTL1KCNJ1SMN1; SMN2 | |
| SCHEMBL16862379 | 0.75 | CYP2D6 (0.44) | KCNJ1SMN1; SMN2ALDH1A1 | |
| SCHEMBL16625875 | 0.74 | CYP3A4 (0.49) | KCNJ1SMN1; SMN2ALDH1A1 | |
| SCHEMBL16862649 | 0.72 | USP2 (0.41) | NPC1RAB9AKCNJ1SMN1; SMN2ALDH1A1 | |
| SCHEMBL16862422 | 0.72 | CYP2D6 (0.38) | KCNJ1SMN1; SMN2ALDH1A1 | |
| SCHEMBL14138696 | 0.71 | ALDH1A1 (0.34) | KCNJ1SMN1; SMN2KCNH2ALDH1A1 | |
| SCHEMBL17725754 | 0.69 | KCNJ1 (0.43) | KCNJ1 | |
| SCHEMBL17977509 | 0.69 | KCNJ1 (0.34) | KCNJ1SMN1; SMN2KCNH2 | |
| SCHEMBL16897552 | 0.68 | KCNJ1 (0.38) | KCNJ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008080988-A2 | CYCLOPENTANONE DERIVATIVES, METHOD OF SYNTHESIS AND USES THEREOF | NEUROPHARMA, S.A. (ES) | 2008-07-10 | — | — | WO | disclosed |
| EP-1939192-A1 | Cyclopentanone derivatives, method of synthesis and uses thereof | Neuropharma S.A. (ES) | 2008-07-02 | — | — | EP | disclosed |
| EP-1939192-A1 | Cyclopentanone derivatives, method of synthesis and uses thereof | Neuropharma S.A. (ES) | 2008-07-02 | — | — | EP | disclosed |