Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.63 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.63 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.63 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.63 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.63 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2323586 | 0.82 | AKR1C3 (0.69) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL2212705 | 0.79 | AKR1C3 (0.68) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL2328747 | 0.78 | AKR1C3 (0.63) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL1625600 | 0.78 | AKR1C3 (0.64) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL3601730 | 0.78 | SIRT6 (0.50) | KMT2ARAB9AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL21113784 | 0.77 | AKR1C3 (0.59) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL31557643 | 0.76 | CYP24A1 (0.49) | AKR1C3AKR1C2KMT2AGAARAB9A | |
| SCHEMBL4588367 | 0.76 | AKR1C3 (0.62) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL1272221 | 0.76 | TRPV1 (0.43) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL4930929 | 0.76 | MAPT (0.68) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7345075-B2 | 6-[(1,2-diphenyl-1H-benzimidazol-6-yl)oxy]hexanoic acid isopropyl ester; antiinflammatory agents; microglia activators; neurodegenerative diseases | SCHERING AKTIENGESELLSCHAFT (DE) | 2008-03-18 | — | — | US | disclosed |
| US-7329679-B2 | 1,2 Diarylbenzimidazoles and their pharmaceutical use | SCHERING AKTIENGESELLSCHAFT (DE) | 2008-02-12 | — | — | US | disclosed |
| US-7115645-B2 | 1,2 diarylbenzimidazoles and their pharmaceutical use | SCHERING AKTIENGESELLSCHAFT (DE) | 2006-10-03 | — | — | US | disclosed |
| US-20060205803-A1 | 1,2 Diarylbenzimidazoles and their pharmaceutical use | SCHERING AKTIENGESELLSCHAFT (DE) | 2006-09-14 | — | — | US | disclosed |
| US-20060094770-A1 | 1,2 Diarylbenzimidazoles and their pharmaceutical use | SCHERING AKTIENGESELLSCHAFT (DE) | 2006-05-04 | — | — | US | disclosed |
| US-20020006948-A1 | 1,2 diarylbenzimdazoles and their pharmaceutical use | SCHERING AG | 2002-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020006948-A1 | 1,2 diarylbenzimdazoles and their pharmaceutical use | CYP2E1, CYP1B1, CYP1A1 | AKR1C3 2106/4885AKR1C2 2339/4885AKR1B1 914/4885 |
| US-20060094770-A1 | 1,2 Diarylbenzimidazoles and their pharmaceutical use | ATP6V1B2, IL1B, GMFG | AKR1C3 2964/4885AKR1C2 3071/4885AKR1B1 1310/4885 |
| US-20060205803-A1 | 1,2 Diarylbenzimidazoles and their pharmaceutical use | ATP6V1B2, IL1B, GMFG | AKR1C3 2964/4885AKR1C2 3071/4885AKR1B1 1310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.