Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | PNMT | P11086 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ADA | P00813 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CTSG | P08311 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | PTPRG | P23470 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL47779 | 0.86 | TAAR1 (0.52) | TAAR1PNMTIDO1SMN1; SMN2NPSR1 | |
| SCHEMBL1821613 | 0.86 | TAAR1 (0.50) | TAAR1PNMTIDO1LMNASMN1; SMN2 | |
| SCHEMBL722953 | 0.83 | IDO1 (0.59) | TAAR1PNMTIDO1LMNASMN1; SMN2 | |
| SCHEMBL28350567 | 0.78 | LMNA (0.38) | IDO1LMNASMN1; SMN2TSHRMEN1 | |
| SCHEMBL5067382 | 0.76 | TAAR1 (0.56) | TAAR1PNMTIDO1ADASMN1; SMN2 | |
| SCHEMBL3897629 | 0.75 | KMT2A (0.49) | TAAR1PNMTIDO1LMNASMN1; SMN2 | |
| SCHEMBL28339916 | 0.75 | LMNA (0.43) | LMNASMN1; SMN2MEN1KMT2APDCD1LG2 | |
| SCHEMBL29760897 | 0.74 | PNMT (0.59) | TAAR1PNMTIDO1LMNASMN1; SMN2 | |
| SCHEMBL3393837 | 0.74 | PNMT (0.59) | TAAR1PNMTIDO1LMNASMN1; SMN2 | |
| SCHEMBL3591795 | 0.74 | TAAR1 (0.46) | TAAR1PNMTIDO1SMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937656-A1 | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS BETA 2 ADRENOCEPTOR AGONISTS | AstraZeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007027134-A1 | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS β2 ADRENOCEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2007-03-08 | — | — | WO | disclosed |