Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.59 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29760897 | 1.00 | PNMT (0.59) | PNMTTAAR1IDO1PKMADRA2A | |
| SCHEMBL9890720 | 0.86 | PKM (0.47) | PNMTTAAR1IDO1PKMADRA2A | |
| SCHEMBL3086828 | 0.85 | PNMT (0.56) | PNMTTAAR1IDO1MEN1KMT2A | |
| SCHEMBL1091961 | 0.85 | PKM (0.64) | PNMTTAAR1IDO1PKMKMT2A | |
| Hydrochloric Acid SCHEMBL7827446 | 0.83 | PKM (0.62) | PNMTTAAR1IDO1PKMKMT2A | |
| SCHEMBL6194277 | 0.83 | PNMT (0.58) | PNMTTAAR1IDO1MEN1KMT2A | |
| SCHEMBL2952259 | 0.82 | P2RX7 (0.47) | PKMADRA2AMEN1KMT2ALMNA | |
| SCHEMBL17328561 | 0.82 | P2RX7 (0.45) | PNMTPKMADRA2AMEN1KMT2A | |
| SCHEMBL6259615 | 0.82 | ALDH1A1 (0.41) | PNMTTAAR1NPSR1ALDH1A1 | |
| SCHEMBL5067382 | 0.81 | TAAR1 (0.56) | PNMTTAAR1IDO1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110053985-A1 | NOVEL PIPERIDINE-4-CARBOXYLIC ACID PHENYL-ALKYL-AMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2011-03-03 | — | — | US | claimed |
| EP-2245011-A1 | NOVEL PIPERIDINE-4-CARBOXYLIC ACID PHENYL-ALKYL-AMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NeuroSearch A/S (DK) | 2010-11-03 | — | — | EP | claimed |
| WO-2009090173-A1 | NOVEL PIPERIDINE-4-CARBOXYLIC ACID PHENYL-ALKYL-AMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2009-07-23 | — | — | WO | claimed |
| EP-0046859-B1 | PROCESS FOR THE PREPARATION OF 1-BROMO-3,5-DICHLOROBENZENE | BASF Aktiengesellschaft (DE) | 1983-07-06 | — | — | EP | claimed |
| CN-101816658-B | HIV inhibiting pyrimidines derivatives | JANSSEN PHARMACEUTICA NV | 2014-08-27 | — | — | CN | disclosed |
| CN-101107234-B | HIV inhibiting 2-(4-cyanophenylamino) pyrimidine derivatives | TIBOTEC PHARM LTD | 2013-06-19 | — | — | CN | disclosed |
| CN-101035773-B | HIV inhibiting 1.2.4-triazin-6-one derivates | JANSSEN PHARMACEUTICA NV | 2012-06-06 | — | — | CN | disclosed |
| CN-101031558-B | HIV inhibiting 5-heterocyclyl pyrimidines | TIBOTEC PHARM LTD | 2011-10-05 | — | — | CN | disclosed |
| CN-102151270-A | Pyrimidine derivatives for the prevention of HIV infection | JANSSEN PHARMACEUTICA NV | 2011-08-17 | — | — | CN | disclosed |
| US-20110053985-A1 | NOVEL PIPERIDINE-4-CARBOXYLIC ACID PHENYL-ALKYL-AMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2011-03-03 | — | — | US | disclosed |
| CN-101119976-B | HIV inhibiting 2-(4-cyanophenylamino) pyrimidine oxide derivatives | TIBOTEC PHARM LTD | 2010-12-22 | — | — | CN | disclosed |
| EP-2245011-A1 | NOVEL PIPERIDINE-4-CARBOXYLIC ACID PHENYL-ALKYL-AMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NeuroSearch A/S (DK) | 2010-11-03 | — | — | EP | disclosed |
| EP-0666744-A1 | USE OF BHAP COMPOUNDS IN COMBINATION WITH OTHER NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS FOR THE TREATMENT OF HIV INFECTION | THE UPJOHN COMPANY (US) | 1995-08-16 | — | — | EP | disclosed |
| EP-0514667-B1 | Benzazepin derivatives as vasopressin antagonists | OTSUKA PHARMA CO LTD (JP) | 1995-08-09 | — | — | EP | disclosed |
| EP-0620003-A1 | VASOPRESSIN ANTAGONIST AND OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-19 | — | — | EP | disclosed |
| US-5244898-A | Vasopressin antagonist | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-09-14 | — | — | US | disclosed |
| EP-0514667-A1 | Benzazepin derivatives as vasopressin antagonists | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-25 | — | — | EP | disclosed |
| EP-0046859-A1 | Process for the preparation of 1-bromo-3,5-dichlorobenzene | BASF Aktiengesellschaft (DE) | 1982-03-10 | — | — | EP | disclosed |
| EP-0000452-B1 | 1,2,4-OXADIAZOL DERIVATIVES, THEIR PREPARATION AND APPLICATION IN PHARMACEUTICAL COMPOSITIONS | SYNTHELABO (FR) | 1981-05-06 | — | — | EP | disclosed |
| EP-0000452-A1 | 1,2,4-Oxadiazol derivatives, their preparation and application in pharmaceutical compositions | SYNTHELABO (FR) | 1979-01-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053985-A1 | NOVEL PIPERIDINE-4-CARBOXYLIC ACID PHENYL-ALKYL-AMIDE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | SLC18A2, SLC6A2, SLC18A3 | PNMT 15/4885TAAR1 41/4885IDO1 392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.