Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.38 |
| ▸ | NPC1 | O15118 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.38 |
| ▸ | RELA | Q04206 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3790001 | 0.78 | CYP3A4 (0.42) | RAB9ANPC1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4591209 | 0.78 | ALDH1A1 (0.36) | RAB9ANPC1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL15546923 | 0.78 | APP (0.44) | RAB9ANPC1ALDH1A1NFKB1NFKB2 | |
| SCHEMBL27839281 | 0.76 | ACHE (0.39) | RAB9ANPC1ALDH1A1SMN1; SMN2ACHE | |
| SCHEMBL28134941 | 0.74 | MMP3 (0.41) | ALDH1A1LMNAGAAKDM4ENOTUM | |
| SCHEMBL6069115 | 0.72 | TSHR (0.44) | RAB9ANPC1ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL197731 | 0.63 | ACHE (0.73) | ALDH1A1LMNAACHETDP1IDO1 | |
| SCHEMBL3287696 | 0.63 | ACHE (0.73) | ALDH1A1LMNAACHETDP1IDO1 | |
| SCHEMBL18661495 | 0.63 | ACHE (0.73) | ALDH1A1LMNAACHETDP1IDO1 | |
| SCHEMBL3860 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1909775-A2 | FORMULATION OF RADIOPROTECTIVE ALPHA, BETA UNSATURATED ARYL SULFONES | Onconova Therapeutics, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007016201-A2 | FORMULATION OF RADIOPROTECTIVE α, β UNSATURATED ARYL SULFONES | ONCONOVA THERAPEUTICS, INC. (US) | 2007-02-08 | — | — | WO | disclosed |