Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4589949 | 0.82 | SIGMAR1 (0.40) | MEN1KMT2AALDH1A1 | |
| SCHEMBL4590444 | 0.71 | SIGMAR1 (0.42) | MEN1KMT2AREN | |
| SCHEMBL5538605 | 0.71 | KMT2A (0.41) | MEN1KMT2AALDH1A1HTTL3MBTL1 | |
| SCHEMBL28528184 | 0.71 | POLB (0.44) | MEN1KMT2AHTR2CALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL6926718 | 0.70 | KMT2A (0.40) | MEN1KMT2AHTR2CALDH1A1HTT | |
| SCHEMBL4566294 | 0.70 | ALDH1A1 (0.40) | MEN1KMT2AALDH1A1HTTL3MBTL1 | |
| SCHEMBL29053190 | 0.67 | MEN1 (0.47) | MEN1KMT2AHTR2CALDH1A1L3MBTL1 | |
| SCHEMBL14412952 | 0.66 | MEN1 (0.71) | MEN1KMT2AHTR2CALDH1A1 | |
| SCHEMBL14740641 | 0.66 | TP53 (0.55) | MEN1KMT2AALDH1A1HTTREN | |
| SCHEMBL23721580 | 0.65 | MEN1 (0.38) | MEN1KMT2AALDH1A1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |