Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.36 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4590446 | 0.82 | MEN1 (0.45) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL19817374 | 0.77 | KDM1A (0.38) | POLBSLC18A3 | |
| SCHEMBL10767178 | 0.73 | AKR1C1 (0.43) | HPGDALDH1A1SLC18A3SLC6A9 | |
| SCHEMBL11081075 | 0.68 | MEN1 (0.74) | SIGMAR1KMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL11085490 | 0.67 | MEN1 (0.77) | SIGMAR1KMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL9452658 | 0.67 | KDM1A (0.33) | — | |
| SCHEMBL9452663 | 0.67 | KDM1A (0.33) | — | |
| SCHEMBL18390858 | 0.66 | MEN1 (0.69) | SIGMAR1KMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL4590449 | 0.65 | MEN1 (0.40) | SIGMAR1KMT2APOLBSMN1; SMN2MEN1 | |
| SCHEMBL5510274 | 0.65 | GAA (0.38) | SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |