Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 13/20 | 0.53 |
| ▸ | DRD2 | P14416 | 10/20 | 0.51 |
| ▸ | HTR2A | P28223 | 9/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4589842 | 0.86 | HTR1A (0.51) | HTR1ADRD2HTR2ADRD3FAAH | |
| SCHEMBL4574004 | 0.78 | DRD2 (0.61) | HTR1ADRD2HTR2ADRD3FAAH | |
| SCHEMBL24684577 | 0.78 | DRD2 (0.53) | HTR1ADRD2HTR2ADRD3HTR2C | |
| SCHEMBL4574561 | 0.77 | DRD2 (0.56) | HTR1ADRD2HTR2ADRD3FAAH | |
| SCHEMBL4574186 | 0.77 | DRD2 (0.60) | HTR1ADRD2HTR2ADRD3FAAH | |
| SCHEMBL4624803 | 0.76 | DRD2 (0.58) | HTR1ADRD2HTR2ADRD3FAAH | |
| SCHEMBL29433199 | 0.72 | DRD2 (0.75) | HTR1ADRD2HTR2AADRA1AHTR2C | |
| SCHEMBL29799389 | 0.72 | DRD2 (0.69) | HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL21026351 | 0.72 | DRD2 (0.69) | HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL17996847 | 0.72 | DTYMK (0.48) | HTR1ADRD2HTR2AADRA1AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008047883-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-04-24 | — | — | WO | disclosed |