Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 10/20 | 0.49 |
| ▸ | GAA | P10253 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | GLA | P06280 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22130286 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2KEAP1MAPTGAAALDH1A1 | |
| SCHEMBL10830079 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2KEAP1MAPTGAAALDH1A1 | |
| SCHEMBL30626914 | 0.81 | NPC1 (0.63) | SMN1; SMN2KEAP1MAPTGAAALDH1A1 | |
| SCHEMBL10047756 | 0.81 | NPC1 (0.63) | SMN1; SMN2KEAP1MAPTGAAALDH1A1 | |
| SCHEMBL20357506 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2KEAP1MAPTGAAALDH1A1 | |
| SCHEMBL27770393 | 0.81 | RAB9A (0.45) | SMN1; SMN2MAPTGAAALDH1A1NPC1 | |
| SCHEMBL3251161 | 0.80 | UBE2T (0.59) | SMN1; SMN2KEAP1MAPTGAAALDH1A1 | |
| SCHEMBL659302 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2KEAP1MAPTGAAALDH1A1 | |
| SCHEMBL27462967 | 0.76 | MAPT (0.61) | SMN1; SMN2MAPTGAAALDH1A1NPC1 | |
| SCHEMBL3203121 | 0.75 | SMN1; SMN2 (0.53) | SMN1; SMN2KEAP1MAPTGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885719-A1 | 2,5- AND 2,6-DISUBSTITUTED BENZAZOLE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | 4SC AG (DE) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006066795-A1 | 2,5- AND 2,6-DISUBSTITUTED BENZAZOLE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | 4SC AG (DE) | 2006-06-29 | — | — | WO | disclosed |