Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA3 | P07451 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15809609 | 0.86 | LTA4H (0.39) | CA12CA2CA3CA4CA6 | |
| SCHEMBL23049142 | 0.82 | CA12 (0.50) | CA12CA2CA3CA4CA6 | |
| SCHEMBL13407442 | 0.81 | LMNA (0.37) | CHRNB2CHRNA4ALDH1A1CYP1A2TDP1 | |
| SCHEMBL21320204 | 0.80 | — | — | |
| SCHEMBL8429697 | 0.80 | — | — | |
| SCHEMBL8416609 | 0.80 | — | — | |
| SCHEMBL26046084 | 0.79 | BHMT (0.32) | ALDH1A1CYP1A2TDP1BHMTHSD17B10 | |
| SCHEMBL15693981 | 0.78 | — | — | |
| SCHEMBL16385287 | 0.78 | CA12 (0.40) | CA12CA2CA3CA4CA6 | |
| SCHEMBL24632215 | 0.78 | CHRM2 (0.31) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881842-A1 | USE OF INHIBITORS OF THE RENIN-ANGIOTENSIN SYSTEM FOR THE TREATMENT OF LUNG INJURIES | IMBA-Institut für Molekulare Biotechnologie GmbH (AT) | 2008-01-30 | — | — | EP | claimed |
| WO-2006122819-A1 | USE OF INHIBITORS OF THE RENIN-ANGIOTENSIN SYSTEM FOR THE TREATMENT OF LUNG INJURIES | IMBA-INSTITUT FÜR MOLEKULARE BIOTECHNOLOGIE GMBH (AT) | 2006-11-23 | — | — | WO | claimed |
| EP-1723962-A1 | Use of inhibitors of the renin-angiotensin system for the treatment of lung injuries | IMBA-Institut für Molekulare Biotechnologie GmbH (AT) | 2006-11-22 | — | — | EP | claimed |
| EP-1881842-A1 | USE OF INHIBITORS OF THE RENIN-ANGIOTENSIN SYSTEM FOR THE TREATMENT OF LUNG INJURIES | IMBA-Institut für Molekulare Biotechnologie GmbH (AT) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006122819-A1 | USE OF INHIBITORS OF THE RENIN-ANGIOTENSIN SYSTEM FOR THE TREATMENT OF LUNG INJURIES | IMBA-INSTITUT FÜR MOLEKULARE BIOTECHNOLOGIE GMBH (AT) | 2006-11-23 | — | — | WO | disclosed |
| EP-1723962-A1 | Use of inhibitors of the renin-angiotensin system for the treatment of lung injuries | IMBA-Institut für Molekulare Biotechnologie GmbH (AT) | 2006-11-22 | — | — | EP | disclosed |