Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 2/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | NMT1 | P30419 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4591152 | 0.86 | NMT1 (0.43) | DHODHNMT1LRRK2 | |
| SCHEMBL4591433 | 0.84 | POLB (0.35) | PDE2APTGESDHODHNMT1LRRK2 | |
| SCHEMBL4591509 | 0.84 | XDH (0.40) | XDHPIM1PIM2DHODHCTSK | |
| SCHEMBL4591714 | 0.82 | KDM4E (0.39) | XDHPDE2APTGESIDH1LRRK2 | |
| SCHEMBL4592213 | 0.82 | PTGES (0.42) | PTGESPIM1PIM2NMT1LRRK2 | |
| SCHEMBL4591409 | 0.82 | LRRK2 (0.34) | PTGESNMT1IDH1LRRK2 | |
| SCHEMBL4591465 | 0.81 | KDM4E (0.40) | XDHPDE2A | |
| SCHEMBL4591626 | 0.80 | PTGES (0.41) | PTGESNMT1LRRK2CYP1A2CYP2C9 | |
| SCHEMBL5181453 | 0.78 | VCAM1 (0.40) | DHODHRECQL | |
| SCHEMBL4592615 | 0.74 | ALOX5AP (0.45) | ALOX5APFEN1XDHPDE2APTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937688-A1 | IMIDAZO BENZODIAZEPINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007042421-A1 | IMIDAZO BENZODIAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-04-19 | — | — | WO | disclosed |