SCHEMBL459113

SCHEMBL459113

Cc1[c]cc(-c2ccc(Cl)cc2)nc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.40
ALDH1A1 P00352 2/20 0.40
NPC1 O15118 7/20 0.40
RAB9A P51151 7/20 0.40
SMN1; SMN2 Q16637 3/20 0.40
METAP2 P50579 1/20 0.39
NOTUM Q6P988 1/20 0.39
KDM1A O60341 1/20 0.38
MAOB P27338 1/20 0.38
NPSR1 Q6W5P4 1/20 0.36
HPGD P15428 3/20 0.35
TP53 P04637 2/20 0.35
LMNA P02545 1/20 0.35
HSD17B10 Q99714 1/20 0.35
MAPK1 P28482 2/20 0.35
USP2 O75604 1/20 0.35
MAPT P10636 2/20 0.35
GAA P10253 1/20 0.35
FYN P06241 1/20 0.35
MEN1 O00255 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL456831 0.81 NPC1 (0.41) KDM4EALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL455476 0.81 LDHA (0.42) KDM4EALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL456889 0.77 KDM1A (0.42) KDM4EALDH1A1KDM1AMAOBHPGD
SCHEMBL15064217 0.77 ALDH1A1 (0.37) KDM4EALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL458803 0.72 CASP1 (0.37) KDM4EALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL8195811 0.71 CCR1 (0.60) KDM4EALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL2614945 0.71 NPC1 (0.47) KDM4EALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL509338 0.70 CYP1A2 (0.42) MAOBNPSR1LMNAMEN1KMT2A
SCHEMBL3061627 0.69
SCHEMBL458927 0.68 NPSR1 (0.44) ALDH1A1NPC1RAB9ASMN1; SMN2NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3045450-B1 INTERMEDIATE COMPOUNDS IN PROCESSES FOR PRODUCING PYRIDAZINONE COMPOUNDS SUMITOMO CHEMICAL CO (JP) 2018-02-07 EP disclosed
EP-3045450-A1 INTERMEDIATE COMPOUNDS IN A PROCESS FOR PRODUCING PYRIDAZINONE COMPOUNDS SUMITOMO CHEMICAL CO., LTD. (JP) 2016-07-20 EP disclosed
EP-2614053-B1 METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATES THEREOF SUMITOMO CHEMICAL CO (JP) 2016-03-23 EP disclosed
CN-103180300-B Process for producing pyridazinone compound and intermediate thereof SUMITOMO CHEMICAL CO.,LTD. (JP) 2015-10-07 CN disclosed
US-9040709-B2 Method for producing pyridazinone compounds and intermediate thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-05-26 US disclosed
CN-104326952-A METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF SUMITOMO CHEMICAL CO 2015-02-04 CN disclosed
CN-104277004-A METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF SUMITOMO CHEMICAL CO 2015-01-14 CN disclosed
EP-2614053-A1 METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2013-07-17 EP disclosed
CN-103180300-A Process for producing pyridazinone compound and intermediate thereof SUMITOMO CHEMICAL CO 2013-06-26 CN disclosed
WO-2012033225-A1 METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-03-15 WO disclosed