Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | XBP1 | P17861 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TACR2 | P21452 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14143944 | 0.87 | CSNK2A1 (0.50) | LMNAALDH1A1HTTMAPTXBP1 | |
| SCHEMBL8431075 | 0.86 | LMNA (0.49) | LMNAALDH1A1MAPTPOLBHPGD | |
| SCHEMBL11864849 | 0.84 | TACR2 (0.51) | LMNAALDH1A1HTTMAPTPOLB | |
| SCHEMBL16200384 | 0.82 | LMNA (0.56) | LMNAALDH1A1HTTMAPTXBP1 | |
| SCHEMBL28612540 | 0.80 | LMNA (0.48) | LMNAALDH1A1HTTMAPTXBP1 | |
| SCHEMBL20615143 | 0.79 | CALM1 (0.58) | LMNAALDH1A1HTTMAPTTSHR | |
| SCHEMBL2559726 | 0.79 | ALDH1A1 (0.63) | LMNAALDH1A1MAPTHPGDTSHR | |
| SCHEMBL6939966 | 0.79 | CSNK2A1 (0.56) | LMNAALDH1A1HTTMAPTXBP1 | |
| SCHEMBL1121617 | 0.79 | LMNA (0.47) | LMNAALDH1A1HTTMAPTXBP1 | |
| SCHEMBL20079748 | 0.79 | LMNA (0.47) | LMNAALDH1A1HTTMAPTXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893603-A1 | PIPERIDIN-4-YL-AMIDE DERIVATIVES AND THEIR USE AS SST RECEPTOR SUBTYPE 5 ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006128803-A1 | PIPERIDIN-4-YL-AMIDE DERIVATIVES AND THEIR USE AS SST RECEPTOR SUBTYPE 5 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-12-07 | — | — | WO | disclosed |