Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.49 |
| ▸ | MBTPS1 | Q14703 | 4/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592042 | 0.92 | REN (0.48) | RENMBTPS1F10PLAUHDAC3 | |
| SCHEMBL4591391 | 0.88 | HDAC3 (0.42) | MBTPS1F10PLAUHDAC3HDAC8 | |
| SCHEMBL4591595 | 0.85 | HDAC3 (0.39) | MBTPS1F10PLAUHDAC3HDAC8 | |
| SCHEMBL4591345 | 0.83 | REN (0.46) | RENMBTPS1F10PLAUSLC6A2 | |
| SCHEMBL4592048 | 0.82 | MEN1 (0.52) | RENSLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL4591350 | 0.82 | REN (0.48) | RENMBTPS1F10PLAUSLC6A2 | |
| SCHEMBL4591451 | 0.81 | HDAC8 (0.43) | MBTPS1F10PLAUHDAC3HDAC8 | |
| SCHEMBL4591502 | 0.79 | HDAC3 (0.40) | RENMBTPS1F10PLAUHDAC3 | |
| SCHEMBL4591877 | 0.78 | REN (0.45) | RENMBTPS1F10PLAUSLC6A2 | |
| SCHEMBL3973371 | 0.78 | L3MBTL1 (0.53) | RENSLC6A2SLC6A4SLC6A3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893603-A1 | PIPERIDIN-4-YL-AMIDE DERIVATIVES AND THEIR USE AS SST RECEPTOR SUBTYPE 5 ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006128803-A1 | PIPERIDIN-4-YL-AMIDE DERIVATIVES AND THEIR USE AS SST RECEPTOR SUBTYPE 5 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-12-07 | — | — | WO | disclosed |