SCHEMBL4591818

SCHEMBL4591818

COc1cc(-c2ccccc2)c([N+](=O)[O-])cc1OC

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.56
TDP1 Q9NUW8 3/20 0.56
MAPT P10636 3/20 0.50
KDM4E B2RXH2 3/20 0.50
CYP3A4 P08684 2/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
ALOX15 P16050 1/20 0.50
PRKDC P78527 1/20 0.50
HSD17B10 Q99714 1/20 0.50
LMNA P02545 1/20 0.49
GAA P10253 2/20 0.48
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
ABCB1 P08183 4/20 0.47
CYP19A1 P11511 1/20 0.47
IDO1 P14902 1/20 0.46
MAPK1 P28482 2/20 0.45
CRHBP P24387 1/20 0.45
CRHR2 Q13324 1/20 0.45
TSHR P16473 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8964813 0.89 ALDH1A1 (0.51) ALDH1A1TDP1MAPTCYP3A4L3MBTL1
SCHEMBL17670218 0.88 TDP1 (0.50) ALDH1A1TDP1MAPTCYP3A4L3MBTL1
SCHEMBL7970512 0.83 RAB9A (0.53) ALDH1A1TDP1MAPTKDM4ECYP3A4
SCHEMBL12844721 0.83 TTR (0.51) ALDH1A1MAPTCYP3A4MEN1KMT2A
SCHEMBL15461976 0.82 ALDH1A1 (0.69) ALDH1A1TDP1MAPTCYP3A4HSD17B10
SCHEMBL7653302 0.81 TDP1 (0.50) ALDH1A1TDP1MAPTCYP3A4L3MBTL1
1,2-Dimethoxybenzene SCHEMBL20540103 0.80 ALDH1A1 (0.71) ALDH1A1TDP1MAPTKDM4ECYP3A4
SCHEMBL22007056 0.80 ALDH1A1 (0.67) ALDH1A1TDP1MAPTCYP3A4HSD17B10
SCHEMBL29021720 0.80 ALDH1A1 (0.43) ALDH1A1TDP1CYP3A4L3MBTL1MEN1
SCHEMBL20581385 0.80 CYP11B1 (0.61) ALDH1A1MAPTKDM4EL3MBTL1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1937238-A1 NOVEL NITROCATECHOL DERIVATIVES HAVING SELECTIN LIGAND ACTIVITY Revotar Biopharmaceuticals AG (DE) 2008-07-02 EP disclosed
WO-2007039114-A1 NOVEL NITROCATECHOL DERIVATIVES HAVING SELECTIN LIGAND ACTIVITY REVOTAR BIOPHARMACEUTICALS AG (DE) 2007-04-12 WO disclosed
US-6194439-B1 ANTICANCER AGENT PFIZER INC. 2001-02-27 US disclosed
EP-0586608-A1 TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS PFIZER INC. (US) 1994-03-16 EP disclosed
WO-1992021660-A1 TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS PFIZER, INC. (US) 1992-12-10 WO disclosed